Woman in traditional Dutch costume in Scheveningen, Netherlands, 1966. The dark shawl in this black-and-white image (black I assume) is an adaptation of the dress worn during mourning.
Background
Summer of 1966 – at the age of 14– I took this candid paparazzi style close-up photo with the all-manual Voigtländer Vito camera below from the beach at the North Sea , looking up at daily life of these women wearing traditional Dutch costumes on the Boulevard in Scheveningen, Netherlands.
Citation info : Scheveningen Woman • Portrait #2 • Michel van der Burg • Miracles•Media • @1MEMO 20251116 • TakeNode 754ed9d9-ef57-47dc-868a-64f55f41ab4b
Close encounter – I was attacked later that day , when getting too close while taking such a portrait photo, but escaped falling backwards. Balinese long-tailed macaque, semi-wild in the Sacred Monkey Forest Sanctuary in Ubud , Bali, Indonesia, Sep. 2000.
Poster 13th Workshop of the AIDSPIT Study Group , Igls (Austria) January 23–25, 1994• Digitally remastered by author, publisher, M.P.M. van der Burg • Miracles•Media • 20251114 • TakeNode 810cc881-d084-4d2e-b252-d432918b1946 • #GLP1
GLP-1 blood sugar regulation in islet transplants
GLP-1 (glucagon-like peptide-1) is now well-known from the anti-diabetic drugs that mimic the action of this natural hormone GLP-1, to treat type 2 diabetes and obesity. They work by stimulating insulin release, reducing glucagon secretion, slowing stomach emptying, and suppressing appetite, which leads to lower blood sugar and weight loss.
May 1992 we were the first to show direct potentiation of the insulin response from isolated islets by a (near-)physiological dose of the gut hormone GLP-1 during perifusion (in vitro) of canine islets at 7.5-10 mM glucose levels (1,2).
Jan 1994 we next showed this incretin effect of GLP-1 also after islet transplantation (in vivo, in dogs) in this poster (3) and abstract (4) presented at the 13th Workshop of the AIDSPIT (aka AIDPIT) Study Group , Igls, Austria, January 23–25, 1994.
Background of the work was posted earlier this year (5) and the work was published Nov 1994 in my PhD thesis Pancreatic islet transplantation , available online (6).
Notes
1) Van der Burg MPM, Guicherit OR, Scherft JP, Frölich M, Terpstra JL, Gooszen HG. Function after intrasplenic transplantation of islets of Langerhans in dogs (translated from dutch: Functie na intralienale transplantatie van eilandjes van Langerhans in de hond). Surgeon days ’92 of the Dutch Surgery Society, Rotterdam (The Netherlands) May 21–22, 1992. In : Gut factors controlling pancreatic islets • 20240910 | Michel van der Burg | michelvanderburg•com URL https://michelvanderburg.com/2024/09/10/gut-factors-controlling-pancreatic-islets-20240910/
2) van der Burg MPM, Guicherit OR, Frölich M, Gooszen HG. Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets. Regul Pept. 1995 Dec 7;60(1):61-7. doi: 10.1016/0167-0115(95)00122-4. PMID: 8747785.
3) Metabolic control after canine islet transplantation. M.P.M. van der Burg, P.T.R. van Suylichem, O.R. Guicherit, J.H.M. van Deijnen, M. Frölich, and H.G. Gooszen (Universities of Leiden & Groningen, The Netherlands). Poster presented at the 13th Workshop of the AIDSPIT Study Group , Igls, Austria, January 23–25, 1994 •
4) Metabolic control after canine islet transplantation. Van der Burg M.P.M., Guicherit O.R., van Suylichem P.T.R., Frölich M., van Deijnen J.H.M. , Gooszen H.G. (Leiden, The Netherlands; Groningen, The Netherlands). Horm metab Res 1994; 26: 63. (Abstract). View/Download file 1MEMO_20251113_2
6) Michael P.M. van der Burg. Pancreatic islet transplantation: studies on the technique and efficacy of islet isolation and transplantation. (Doctoral Thesis, Faculty of Medicine, Leiden University Medical Center (LUMC) , Leiden University), Boskoop: M.P.M. van der Burg | Miracles.Media (ISBN electronic, pdf, 9789080216402 ; ISBN print 9789080216419, 9080216410), 1994: 192 p. URL Thesis Repository Leiden University https://hdl.handle.net/1887/3486604
PM – Recording of the 13th AIDSPIT seminar on lessons from clinical islet transplantation was posted yesterday (7).
Citation info : GLP-1 blood sugar regulation in islet transplants • AIDSPIT 1994 • Michel van der Burg • Miracles.Media • @1MEMO 20251114 • TakeNode 810cc881-d084-4d2e-b252-d432918b1946 • URL https://michelvanderburg.com/2025/11/14
Seminar on lessons from clinical islet transplantation
Chairman K. Federlin (Giessen, Germany) opened the seminar Tuesday, January 25, 1994 and David Scharp began with his lesson from the Center in St. Louis (USA) at the 13th Workshop of the AIDSPIT * Study Group , Igls, Austria, January 23–25, 1994.
Notes
Video image: Iodixanol-UWS purified human islets, stained with dithizone (March 18, 1999) • Michel van der Burg , Leiden Islet Laboratory LUMC .
Second, remastered, edition created from the 1st video edition published 20170208 via Vimeo at 1-memo.com .
* AIDSPIT later known as AIDPIT.
Recorded with Olympus mini-tape dictaphone, and re-recorded from the speaker of the dictaphone.
My presentations at the event
Cell preservation in University of Wisconsin solution during isolation of canine islets of Langerhans. Van der Burg M.P.M., Guicherit O.R., Frölich M., Gooszen H.G. (Leiden, The Netherlands) . Horm metab Res 1994; 26: 63. (Abstract). File 1MEMO_20251113_2
Metabolic control after canine islet transplantation. Van der Burg M.P.M., Guicherit O.R., van Suylichem P.T.R., Frölich M., van Deijnen J.H.M. , Gooszen H.G. (Leiden, The Netherlands; Groningen, The Netherlands). Horm metab Res 1994; 26: 63. (Abstract). File 1MEMO_20251113_2
Front page Acta Diabetologica • Download Abstract Below
Abstract published in Acta Diabetologica 1998 of Iodixanol-UWS Human Islet Purification in 1998 at the Diabetes Research Institute in Miami. Abstracts book of the 18th Workshop of the AIDSPIT Study Group in Igls, Austria, Jan 1999.
Van der Burg MPM, Ranuncoli A, Molano R, Kirlew T, Ringers J, Bouwman E, Ricordi C. Efficacy of the novel iodixanol-UWS density gradient for human islet purification (Abstract). Acta Diabetol 1998; 35: 247. View / Download abstract (file 1MEMO_20251102_1.pdf) below .
Abstract added in full post : Efficacy of the novel iodixanol-UWS density gradient for human islet purification • Igls Aidspit 1999 • 20241202 • URL michelvanderburg.com/2024/12/02 •
Citation info : Iodixanol-UWS Human Islet Purification 1998 Abstract • Michel van der Burg • Miracles.Media • @1MEMO 20251102 • URL michelvanderburg.com/2025/11/02/
Citation info : Youtube Top 50 • Hessel & Tess • Michel van der Burg • Miracles•Media • @1MEMO 20251024 • TakeNode d8fa14f3-c24a-4a6d-be9b-89436045bb64 / f407ea33-2b69-43ae-93af-f8d34516bdfa
