St Edmund Hall, University of Oxford, July 1989 • Michel van der Burg • Miracles•Media • 20241019_1 • TakeNode af426345-4fb3-48a3-8d5e-4368c56826aa
Venue of the Seventh Annual Meeting of the Anglo–Danish–Dutch Diabetes Group*, Oxford (UK) July 5–9, 1989.
The first international meeting were our new concept was presented, of pancreatic islet isolation in the University of Wisconsin Solution (UW-Solution or UWS) a solution designed recently for preservation of a donor pancreas during cold storage prior to transplantation.
Quote :
“…A few months ago, we adopted an entirely new approach to islet isolation. Recently a new cold storage organ preservation solution was developed at the University of Wisconsin, the UW solution, allowing long term, 24 to 72 h, cold storage of the canine pancreas. Since islet isolation is largely performed in the cold, we tested this preservation solution as the isolation medium throughout the isolation procedure. This slide shows that using the UW solution, purity has increased to over 90%…”
In addition our first successful pre-clinical transplant, we had performed the last month, was reported as breaking news at the end of the talk.
Quote :
“Three weeks ago we did our first autotransplantation of isolated islets from the whole gland by retrograde infusion into the spleen. The dog is doing fine: fasting glucose amounts to 5-6 mM and postprandial glucose between 6-8 mM ; postprandial insulin increases 6-7 fold. Thank you.”
St Edmund Hall, Oxford, 1989, 7th Meeting ADDD Group • Michel van der Burg • Miracles•Media • 20241019_2 • TakeNode ca40adf0-3b86-4ada-93a8-126c6768d420
Notes
Seventh Annual Meeting Anglo Danish Dutch Diabetes Group • Michel van der Burg • Miracles•Media • 20241019_3 • TakeNode bffdea47-9464-4f7b-8299-ec299d41ca4d
* Group supported through the Nordisk UK Professional Programme.
Van der Burg MPM, Gooszen HG, Scherft JP, Terpstra JL, Frölich M, Guicherit OR, Lemkes HHPJ, Bruijn JA. The isolation of canine pancreatic islets for transplantation. Seventh Annual Meeting Anglo Danish Dutch Diabetes Group, Oxford (UK) July 5–9, 1989.
Van der Burg MPM, Gooszen HG, Guicherit OR, Jansen JBMJ, Frölich M, Lamers CBHW. The mechanism of pancreatic duct obliteration induced hyperglycemia. Seventh Annual Meeting Anglo Danish Dutch Diabetes Group, Oxford (UK) July 5–9, 1989.
Citation info : ADD Diabetes Group 1989, St Edmund Hall, Oxford • Michel van der Burg • Miracles•Media • 20241019 • URL michelvanderburg•com
Sinclair’s ZX81 computer (1KB on-board memory , with a 64K memory expansion module inserted at the back) – my first PC – that I started using from 1983 for automation of work in our experimental pancreas and islet transplantation research project – for creating (‘coding’) and using the entire suit of apps, needed for the raw data processing and the (statistical and pharmacokinetic) analysis.
The hardware set-up included a TV (B/W) as monitor, (mono audio) tape recorder for data storage (apps), and a small thermal printer.
Citation info : ZX81 • Michel van der Burg • Miracles•Media • 20241018 • TakeNode 9c595df8-8091-497c-9c9c-ff85fe4de397 • URL michelvanderburg•com
October 15, 2024 — Watch free online the full documentary “The Jews of Corfu” – a film by Mirjan Gjergjevica & Maria Boua (1) .
Documentary “The Jews of Corfu” – a film by Mirjan Gjergjevica & Maria Boua
The Jews of Corfu – Review
The Jews of Corfu – a population group that was an important part of the island, contributed to the formation of its history. But the tragic events that befell them were added to the black page of human history. The film The Jews of Corfu (2021) is a powerful documentary by Mirjan Gjergjevica (direction, cinematography, editing, production) & Maria Boua (script, music, sound, production) with narration by Yannis Andriotis and stories told by Zaharias Matathias • Linos Sousis • Nina Vital. Powerful — both visually and the sound — filmed in an innovative way, combining ambient sound and stories told outdoors with the Mediterranean background, in public spaces, the streets, and Corfu synagogue – with an excellent film score – that is especially impressive how it manages to accompany the viewer in scenes of holocaust atrocities. The history of the Corfiot Jews – a mixture of Pugliese (from south Italy) and Romaniote (from Greece) is told in vivid detail from the Middle Ages to today. I watched this fast paced film twice, last premiere weekend, to fully grasp the whole picture ~ Michel van der Burg – Monday , March 14, 2022 (2).
Film festivals & education & online
The free public release of the film was announced last Saturday (Oct 12, 2024) by filmmaker Mirjan Gjergjevica (3) :
“It is with great pleasure and honor that we present to public our documentary, The Jews of Corfu. This work has been screened in many festivals around the world, from America to Australia, and has been lovingly embraced by schools and universities. Now, we are happy to share this freely with you all. I warmly thank all the main contributors who contributed to the realization of this documentary: Maria Boua, Christiana Latsa, Yiannis Andriotis, Anthi Kyrtsoglou, Giorgos Zumbos and all those who helped directly or indirectly. We hope this documentary continues to convey its message to even more people and be a way to learn about the history of the Jews of Corfu.”
Mirjan added in an update Oct 13, 2024 :
“We would like to clarify that the present publication of the documentary is not related to the recent war events that are taking place. We condemn all forms of violence and conflict, and we strongly advocate peace and reconciliation among the peoples. “
Miracles•Media • 20241011_1 • Harzburger Front founding field service with preacher Bruno Doehring on the Kaltental-Wiese (meadow) in Bad Harzburg, October 11, 1931.
Founding of the ‘Harzburger Front’ in Bad Harzburg, October 11, 1931 – an alliance between right-wing, nationalist, conservative elements and Hitler, to attempt to topple the Weimar government of chancellor Heinrich Brüning. The field service on the Kaltental-Wiese (meadow) in Bad Harzburg, with the Berlin Protestant preacher Bruno Doehring, on the platform (pulpit).
Miracles•Media • 20241011 2 • Nazi Party at the founding of the ‘Harzburger Front’ in Bad Harzburg, October 11, 1931. Bundesarchiv image 102 02134 • CC BY SA 3.0
The Nazi Party delegation during the field service on the Kaltental-Wiese (meadow) in Bad Harzburg. First row , left to right: Gerret Korsemann (SA-leader), Heinrich Himmler (SS Chief), Ernst Röhm (SA Chief), Franz Ritter von Hörauf, Hermann Göring (Reichsmarschall, Commander-in-Chief of the Luftwaffe, Prime Minister of Prussia), Bernhard Rust (Prussian Minister of Culture).
Notes
Last update 20241011-2228
Update 20241011-2228 : Facebook does not allow me to share todays post with images from my website michelvanderburg•com or michelvanderburg.substack (posts are removed)
Citation info : Radical Right Front • Miracles•Media • 20241011 • URL michelvanderburg.com/2024/10/11/
LUMC, 11 June 2003, Leiden, Holland • Michel van der Burg • Miracles•Media • 20241010_1 • TakeNode 2d46097b-ca09-442d-9cf5-fc347a27fc46 | Image shot using the Konica Revio C2 – my first digital camera.
While searching my archive today, I encountered the Press release Sep 27, 2001 of the dutch National Health Care Institute (CVZ), advicing the Ministry of Health, Welfare and Sport (VWS) to grant permission for Transplantation of Islets of Langerhans in the Leiden University Medical Center (LUMC).
Greek Poster • Michel van der Burg • Miracles•Media • 20241009
Funny. LibreOffice Vanilla Issue.
Greek characters appeared in this poster originally designed with english text and produced on a Macintosh computer and Imagewriter dotmatrix printer, September 3, 1990, using the MacDraw II application, with graphs from Cricket Graph. That 1990 Mac file was remastered today in LibreOffice Vanilla (other minor issues in graphs not corrected). Generally LibreOffice does a great job with these ancient files. I recently posted several of such posters at site michelvanderburg.com. However, some of the posters retrieved from my archive show up with Greek characters when opened in LibreOffice, like this poster produced in English (with roman characters). Those problematic posters have in common that the Apple Chicago font was used – the interface font in Apple’s early versions of Mac OS from 1984 to 1997. Clearly LibreOffice cannot handle this Chicago font correctly. I have not found a solution for this. Text in other posters, produced with Helvetica, had only minor issues in LibreOffice, Helvetica italics text appeared as regular Times.
The original poster and abstract (below) were presented at the 8th International Symposium on Gastrointestinal Hormones, in Timmendorfer Strand Baltic Sea (FRG) September 4–8, 1990.
Abstract
Contribution of gut factors to canine isolated islet function M.P.M. van der Burg, O.R. Guicherit, J.B.M.J. Jansen, C.B.H.W. Lamers, J.P. Scherft, M. Frölich, H.G. Gooszen. Departments of Surgery, Gastroenterology. Endocrinology and Cel Biology. University Hospital, Leiden, The Netherlands. Techniques for isolating islets of Langerhans from the large mammalian pancreas have improved to the point where islet transplantation as a therapeutical approach to human diabetes has become more realistic. The quality of metabolic control is however largely unknown. We studied canine isolated-islet function both in vivo after autotransplantation, as well as in vitro by perifusion. Five normal dogs underwent total pancreatectomy. Islets were isolated from the excised pancreas by collagenase digestion, dispersion and purification with filtration and density gradients. Isolated islets were autotransplanted into the spleen of the dog by retrograde venous infusion. Graft function was assessed up to 3 mo by determining the glucose and insulin response to an intravenous glucose injection (IVGTT), i.v. arginine injection during 35 mM glucose clamp (AT), and a meal. In addition (n = 4) the in vitro insulin response of overnight cultured canine islets was studied by perifusion with cholecystokinin (CCK-33) and glucose-dependent insulinotropic polypeptide (GIP). The islet dose at transplantation ranged from 3500 – 13000 islets/kg b.w. One animal became overtly hyperglycemic (fasting glucose 18 mM) within 7 days after receiving 3500 islets/kg b.w. The other grafts (> 6000 islets/kg b.w.) were successful (fasting glucose <7mM) but demonstrated, compared to pre-operative values, a 50% reduced glucose clearance and insulin response at IVGTT, and a 90% reduced insulin secreting capacity at AT. Postprandially hyperglycemia (~ 10 mM) and in contrast to i.v. glucose and arginine, a normal insulin response was observed. The in vitro insulin response at 7.5 mM glucose to equimolar (0.1-1- 10 nM) concentrations of either CCK, GIP or both, demonstrated a sustained dose-response to GIP (up to 5x basal values) and a significant albeit small and transient effect of CCK as of 1 nM. No synergistic effect was observed. In dogs ‘one-to-one’ transplantation was successful in 4/5 recipients of isolated islets. The difference in the effect of islet transplantation on the insulin response to intravenous glucose or – arginine and a meal, may be related to the postprandial, hyperglycemia enhanced, activation of the entero-insular axis, especially GIP.
Van der Burg MPM, Guicherit OR, Jansen JBMJ, Lamers CBHW, Scherft JP, Frölich M, Gooszen HG. Contribution of gut factors to canine isolated islet function (Abstract). Digestion 1990; 46 (Suppl 1): 14–15. https://doi.org/10.1159/000200356
PDF abstract shown below – file 20241009_1_Digestion.pdf
Citation info : Greek Poster • Michel van der Burg • Miracles•Media • 20241009 • URL michelvanderburg.com/2024/10/09 | TakeNode 10afaddd-08b7-4dcd-ad7a-43228420ad59
