Tag Archives: holland

Bridge 65 to the Jordaan ~ Amsterdam Streets

Bridge 65 to the Jordaan ~ Amsterdam Streets
Street view on the ‘Bears sluice’ (Berensluis – bridge 65) over the Prinsengracht canal – port to the Jordaan district – in the center of Amsterdam , yesterday at twilight during rush hour, 5 PM January 7, 2020. Film : 20200108 Michel van der Burg | 1-memo.com

Twilight Arrival – Terschelling Island

Twilight Arrival Terschelling Island
Friesland ferry (Doeksen company) arriving in the harbor of West-Terschelling on the dutch Wadden Sea island Terschelling at low tide last Christmas Day at 4:40 PM. Film : 20200101 Michel van der Burg | 1-memo.com

Flammable Films Bunker

Flammable Films Bunker
Former german bunker (Atlantic Wall) in the dunes along the North Sea near Scheveningen , The Hague, with special safes to store the flammable nitrate films of dutch history from the national dutch archive – historic films for safety reasons not allowed within built-up areas.
Here the Westerbork film footage also was examined in the 1990s for clues about the deportation trains and the name of the girl with the ‘working’ name Esther (by researcher Aad Wagenaar) – later to be identified as Settela.
Here a 1980 Polygoon newsreel on the restauration of this RVD archive bunker with new safes.

Credit
Source : Polygoon-Profilti (producer) / Netherlands Institute for Sound and Vision (curator).
Film edit ‘Flammable Films Bunker’ (20191216) by Michel van der Burg | Settela.com – licensed CC BY-SA 4.0

Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients


Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients.
Here a film made of my ‘powerpoint’ presentation Feb 22, 2000 – on behalf of our Surgical Department – at the Opening Symposium of the Interdivisional GMP (‘Good Manufacturing Practice’) facility of the Leiden University Medical Centre – the LUMC in Leiden, Holland.

Background
I first started – with a background in biochemistry and philosophy – some 20 years earlier (from 1981) research at the Department of Surgery of the Leiden University Hospital (AZL) in the field of transplantation of the pancreas organ to cure diabetes.

Succesful Experiment Islet Transplantation
From 1986 my focus shifted to innovative procedures for the isolation out of the pancreas organ, of the ca 1 million islets of Langerhans – the insulin producing cell clumps with a size between ca 0.1 to 1 mm , that is 0.004 to 0,04 inch.
In 1989 we performed the first successful autologous transplantations in Holland (in collaboration with the Minneapolis Islet Lab with Jane Field and David Sutherland) – for the first time world-wide with pure islets using our novel procedure of using the organ preservation UW solution (University of Wisconsin / collaboration with dr Robert Carter , Du Pont, UK) during isolation in a pre-clinical large animal diabetes model – with long term transplant functioning with near-normal blood sugar regulation.

First series of human islet isolations , 1989-1990
Next in 1989-1990 we performed a first series of islet isolations from human donor pancreases using our novel techniques of isolation and purification in UW organ preservation solution – in association with a European Concerted Action for the Treatment of Diabetes – the Brussels headed (Daniel Pipeleers) ‘Multicenter program on the treatment of diabetes by islet cell transplantation’.

Exploring human islet work
Subsequently – after some years of exploring options for animal to human islet transplantation , using pig pancreas islets – so-called xenotransplantation – I was asked in 1997 to explore the requirements for operationalization of clinical islet transplantation in the LUMC. December 1997 our Surgical Department decided to go for it.

Establishing the human islet isolation laboratory in Leiden.
In 1998 after a month working in dr Camillo Ricordi’s Diabetes Research Institute in Miami, I started a large series of human islet isolation procedures in Leiden, and from september 1998 documenting the detailed GMP (‘Good Manufacturing Practice’) standard operating procedures, as well as ‘building’ our clinical islet isolation clean room with help from the Miami team in close cooperation with dr. Amon Wafelman (department of Clinical Pharmacy & Toxicology) managing the building of our brand new Interdivisional GMP-facility LUMC (IGFL) of six clean rooms and two chemical product laboratories – that was opened officially Feb 22, 2000 with the symposium, a film, and a tour in the GMP facility.
One year later the GMP islet facility was fully operational and summer 2001 we got a cautious green light (GMP license) for clinical transplantation of any high quality – approved – islet preparations.
Around the same time islet transplantation suddenly became very promising with ‘The Edmonton protocol’. However with the fast increase of logistic and financial demands, and reorganization between LUMC divisions it took till 2007 to finally start first transplants by an expanded islet team in the LUMC clinical islet center in Leiden.
Worldwide since 2000 several hundred people have received islet transplants that generally do not result in long term insulin independence , but do help sugar regulation in the transplant recipients.

Notes :
Links to some publications, news paper reports etc will follow later.

Updates:

Post updated with more details 20191215

Presentation ‘Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients’ by Michel van der Burg, Feb 22, 2000 – Opening Symposium of the Interdivisional GMP facility of the Leiden University Medical Centre, Leiden, Netherlands. Film : 20191213 Michel van der Burg | miracles.media

Paul Verhoeven : Jesus The Man

PAUL VERHOEVEN : JESUS THE MAN

NL – 10 jaar geleden – dinsdag 31 maart 2009 – kwam regisseur en schrijver Paul Verhoeven op uitnodiging van het Instituut der Godsdienstwetenschappen van de Leidse universiteit naar Leiden , om te praten over zijn boek ‘Jezus van Nazaret’ …. ‘een realistisch portret’ dat eind 2008 was uitgegeven (geschreven in samenspraak met Rob van Scheers).
Naast cinema kent Nederlands grootste filmregisseur Paul Verhoeven nóg een levenslange fascinatie: Jezus van Nazareth. Na zijn vertrek uit Nederland in 1985 meldde hij zich daarom in Californië aan bij het zogeheten Jesus Seminar, een hoog aangeslagen wetenschappelijke denktank van zo’n zeventig eminente professoren in godgeleerdheid, filosofie, linguïstiek en bijbelgeschiedenis, opgericht door Amerika’s meest vooraanstaande liberale exegeet Robert W. Funk.
Als enige niet-theoloog mocht Verhoeven aanschuiven bij de discussies die tot doel hadden de historische figuur Jezus van de mythische bijbelfiguur Jezus te bevrijden, hem te ontdoen van tweeduizend jaar christelijke inkleuring. Als bijdrage aan dit onderzoek schreef Paul Verhoeven – in Leiden afgestudeerd in wis- en natuurkunde – vele wetenschappelijke papers die vervolgens de basis vormden voor zijn spraakmakende boek Jezus van Nazaret – inmiddels in meerdere vertalingen uitgegeven .
Een discussie met Paul Verhoeven in een panel met Prof. Jürgen Zangenberg, dr Wim Hofstee, en studenten – met een introductie door dr Peter Verstraten – in de Lokhorstkerk te Leiden.
Een reportage van 45 min beeld van de 2 uur durende discussie – gefilmd met een Sony T500 compact camera.
NB : Een deel (ca 17 min) van deze reportage verscheen eerder, 3 april 2019, in een post getiteld ‘JESUS THE MAN – FILMMAKER PAUL VERHOEVEN’ (20190403 – https://michelvanderburg.com/2019/04/03/jesus-the-man-filmmaker-paul-verhoeven/ ).

EN – Filmmaker Paul Verhoeven’s project Jesus of Nazareth – a realistic portrait. Discussion with Paul Verhoeven March 31 , 2009 in dutch on his fascination for ‘Jesus the man’, his study in the Jesus Seminar, and the making of his book (based on interviews with Rob van Scheers) published a few months earlier – 10 years ago.
Paul Verhoeven was invited by the Institute of Religious Studies at the Leiden University on March 31 , 2009 in the Lokhorst church in Leiden , Holland.
A 45 min report of the 2 hours discussion – filmed with a Sony T500 compact camera.
Note : Part of this film (ca 17 minutes) was reported April 3, 2019 in the preliminary post JESUS THE MAN – FILMMAKER PAUL VERHOEVEN (20190403 – https://michelvanderburg.com/2019/04/03/jesus-the-man-filmmaker-paul-verhoeven/ ).

Credits
PAUL VERHOEVEN : JESUS THE MAN
March 31 , 2009 – Discussion Paul Verhoeven with Leiden University Prof Jürgen Zangenberg, dr Wim Hofstee, dr Peter Verstraten, students and public in Lokhorstkerk church , Leiden , Holland.
Film ‘PAUL VERHOEVEN : JESUS THE MAN’ (20191117) by Michel van der Burg – michelvanderburg.com | miracles.media

Horses at Sunset

Horses at Sunset
Horses at sunset in the polder grasslands around Alphen in Holland, November 2015. Pinhole film using a SLR Magic ‘Toy’ Pin Hole cap – f/128 aperture, 12mm focal length (24mm-equivalent), 84° angle view – mounted on a Olympus Micro Four Third camera (E-PM1). Music : Carousel by Yehezkel Raz | Artlist
Film : 20191112 Michel van der Burg | 1-memo.com | miracles.media