Tag Archives: history

Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients


Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients.
Here a film made of my ‘powerpoint’ presentation Feb 22, 2000 – on behalf of our Surgical Department – at the Opening Symposium of the Interdivisional GMP (‘Good Manufacturing Practice’) facility of the Leiden University Medical Centre – the LUMC in Leiden, Holland.

Background
I first started – with a background in biochemistry and philosophy – some 20 years earlier (from 1981) research at the Department of Surgery of the Leiden University Hospital (AZL) in the field of transplantation of the pancreas organ to cure diabetes.

Succesful Experiment Islet Transplantation
From 1986 my focus shifted to innovative procedures for the isolation out of the pancreas organ, of the ca 1 million islets of Langerhans – the insulin producing cell clumps with a size between ca 0.1 to 1 mm , that is 0.004 to 0,04 inch.
In 1989 we performed the first succesful autologous transplantations in Holland – for the first time world-wide with pure islets – in a pre-clinical large animal diabetes model with long term transplant functioning with near-normal blood sugar regulation.
Around that time (1990) first preliminary isolations from human donor pancreases were done too.

Exploring human islet work
Subsequently – after some years of exploring options for animal to human islet transplantation , using pig pancreas islets – so-called xenotransplantation – I was asked in 1997 to explore the requirements for operationalization of clinical islet transplantation in the LUMC. December 1997 our Surgical Department decided to go for it.

Establishing the human islet isolation laboratory in Leiden.
In 1998 after a month working in dr Camillo Ricordi’s Diabetes Research Institute in Miami, I started a large series of human islet isolation procedures in Leiden, and from september 1998 documenting the detailed GMP (‘Good Manufacturing Practice’) standard operating procedures, as well as ‘building’ our clinical islet isolation clean room with help from the Miami team in close cooperation with dr. Amon Wafelman (department of Clinical Pharmacy & Toxicology) managing the building of our brand new Interdivisional GMP-facility LUMC (IGFL) of six clean rooms and two chemical product laboratories – that was opened officially Feb 22, 2000 with the symposium and a tour and film in the GMP facility.
One year later the GMP islet facility was fully operational and summer 2001 we got a cautious green light (GMP license) for clinical transplantation of any high quality – approved – islet preparations.
Around the same time islet transplantation suddenly became very promising with ‘The Edmonton protocol’. However with the fast increase of logistic and financial demands, and reorganization between LUMC divisions it took till 2007 to finally start first transplants by an expanded islet team in the LUMC clinical islet center in Leiden.
Worldwide since 2000 several hundred people have received islet transplants that generally do not result in long term insulin independence , but do help sugar regulation in the transplant recipients.

Notes :
Links to some publications, news paper reports etc will follow later.

Presentation ‘Isolation of Islets of Langerhans for Transplantation in Type-1 Diabetic Patients’ by Michel van der Burg, Feb 22, 2000 – Opening Symposium of the Interdivisional GMP facility of the Leiden University Medical Centre, Leiden, Netherlands. Film : 20191213 Michel van der Burg | miracles.media

Paul Verhoeven : Jesus The Man

PAUL VERHOEVEN : JESUS THE MAN

NL – 10 jaar geleden – dinsdag 31 maart 2009 – kwam regisseur en schrijver Paul Verhoeven op uitnodiging van het Instituut der Godsdienstwetenschappen van de Leidse universiteit naar Leiden , om te praten over zijn boek ‘Jezus van Nazaret’ …. ‘een realistisch portret’ dat eind 2008 was uitgegeven (geschreven in samenspraak met Rob van Scheers).
Naast cinema kent Nederlands grootste filmregisseur Paul Verhoeven nóg een levenslange fascinatie: Jezus van Nazareth. Na zijn vertrek uit Nederland in 1985 meldde hij zich daarom in Californië aan bij het zogeheten Jesus Seminar, een hoog aangeslagen wetenschappelijke denktank van zo’n zeventig eminente professoren in godgeleerdheid, filosofie, linguïstiek en bijbelgeschiedenis, opgericht door Amerika’s meest vooraanstaande liberale exegeet Robert W. Funk.
Als enige niet-theoloog mocht Verhoeven aanschuiven bij de discussies die tot doel hadden de historische figuur Jezus van de mythische bijbelfiguur Jezus te bevrijden, hem te ontdoen van tweeduizend jaar christelijke inkleuring. Als bijdrage aan dit onderzoek schreef Paul Verhoeven – in Leiden afgestudeerd in wis- en natuurkunde – vele wetenschappelijke papers die vervolgens de basis vormden voor zijn spraakmakende boek Jezus van Nazaret – inmiddels in meerdere vertalingen uitgegeven .
Een discussie met Paul Verhoeven in een panel met Prof. Jürgen Zangenberg, dr Wim Hofstee, en studenten – met een introductie door dr Peter Verstraten – in de Lokhorstkerk te Leiden.
Een reportage van 45 min beeld van de 2 uur durende discussie – gefilmd met een Sony T500 compact camera.
NB : Een deel (ca 17 min) van deze reportage verscheen eerder, 3 april 2019, in een post getiteld ‘JESUS THE MAN – FILMMAKER PAUL VERHOEVEN’ (20190403 – https://michelvanderburg.com/2019/04/03/jesus-the-man-filmmaker-paul-verhoeven/ ).

EN – Filmmaker Paul Verhoeven’s project Jesus of Nazareth – a realistic portrait. Discussion with Paul Verhoeven March 31 , 2009 in dutch on his fascination for ‘Jesus the man’, his study in the Jesus Seminar, and the making of his book (based on interviews with Rob van Scheers) published a few months earlier – 10 years ago.
Paul Verhoeven was invited by the Institute of Religious Studies at the Leiden University on March 31 , 2009 in the Lokhorst church in Leiden , Holland.
A 45 min report of the 2 hours discussion – filmed with a Sony T500 compact camera.
Note : Part of this film (ca 17 minutes) was reported April 3, 2019 in the preliminary post JESUS THE MAN – FILMMAKER PAUL VERHOEVEN (20190403 – https://michelvanderburg.com/2019/04/03/jesus-the-man-filmmaker-paul-verhoeven/ ).

Credits
PAUL VERHOEVEN : JESUS THE MAN
March 31 , 2009 – Discussion Paul Verhoeven with Leiden University Prof Jürgen Zangenberg, dr Wim Hofstee, dr Peter Verstraten, students and public in Lokhorstkerk church , Leiden , Holland.
Film ‘PAUL VERHOEVEN : JESUS THE MAN’ (20191117) by Michel van der Burg – michelvanderburg.com | miracles.media

Nobody No Longer Nobody – ID Card Propaganda 1940


Cinema propaganda newsreel (Polygoon) September 1940 on a rush for portrait photos needed for the ‘Persoonsbewijs’ , the ID card.
After the German invasion in 1940 the Dutch aged 15 and older were required to carry identity cards (called ‘persoonsbewijs’). This later led to the death of many people.

Polygoons Hollands Nieuws newsreel courtesy of Netherlands Institute for Sound and Vision (Open Images).

① memo 20190825 ~ Nobody No Longer Nobody – ID Card Propaganda 1940

Hollywood in Holland – Barnstijn’s FILMSTAD Opening 1935


Film City “Filmstad Wassenaar” – his film studio complex in Wassenaar near The Hague – is opened in 1935 by the dutch jewish cinema operator , film distributor and producer Loet C. Barnstijn (born in 1880 as Lodewijk Cohen) starting you might say a Hollywood in Holland. After first working in textiles, he sold his business to start in the film business as a cinema operator. He was a film distributor , an inventor with Philips of a synchronized sound system using records .. the Loetafoon, and introduced the sound film in Holland in the early 1930s. During the war Filmstad was confiscated, and became UFA Filmstadt Den Haag. The allies bombed the complex in 1944. After the war Barnstijn lived in the USA were he died in 1953.
Cinema newsreel, October 1935, from Polygoon courtesy of Netherlands Institute for Sound and Vision (Open Images).

Sound (speeches) starts after arrival of the guests at 3 min 20 sec.

Yesterday I posted on his first production the artistic documentary “Sjabbos“.

① memo 20190824 ~ Hollywood in Holland – Barnstijn’s FILMSTAD

Sjabbos

Film link : http://www.oorloginblik.nl/film/niod/2759421

Sjabbos | Friday Night (1932) avant garde film documentary made by dutch filmmaker Jan Teunissen (G.J. Teunissen) on the Amsterdam Jewish Quarter when sabbath starts.
It’s the first film presented by the dutch jewish film producer Loet C. Barnstijn – and as and artistic documentary , different from his later films. Sound by Polygoon Haarlem and Tobis-Klangfilm, Studios Éclair Paris-Èpinay-sur-Seine.

Pre-war Amsterdam’s Jewish quarter at the start of the shabbat: street life with shops and market, the Zuidertoren tower strikes 4 o’clock and the sabbath starts. The shops are closing, businesses are being shut down, employees are rushing home.
While the women at home put the finishing touches to the meal, carefully set the table and light the candles, the men hurry to the synagogue. Chazan Blanes enters the Snoge (Portuguese Synagogue) through the side gate, cantor Maroko greets the shabbat in the Grote Synagoge (Great Synagogue).

Jan Teunissen joined the National Socialist Movement in the Netherlands in 1940, benefactor member of the dutch SS in 1941 and head of the Filmgilde – the film section of the dutch ‘Kultuurkamer’ – the NS propaganda organisation in Holland during WW2.
Fragments of this film where used in 1941 in the dutch version of the Nazi antisemitic propaganda film “The eternal Jew”.
After the war Jan Teunissen was detained 3 years and subsequently prohibited from working in the Dutch film industry for ten years.

References
http://www.oorloginblik.nl/film/niod/2759421
https://www.eyefilm.nl/en/collection/film-history/person/jan-teunissen https://nl.wikipedia.org/wiki/Jan_Teunissen
https://www.youtube.com/watch?v=BTMN_QOrdKQ

Mokum Market ~ Amsterdam Jewish Quarter 1931 (update)


① memo 20190815 ~ Mokum Market ~ Amsterdam Jewish Quarter 1931 ~ New version of yesterday’s (20190814) film – slowed to 75%*. Sunday outdoor market in the ‘Nieuwe Uylenburgerstraat’ street in the Jewish quarter of Amsterdam (Mokum). Dutch Polygoon cinema newsreel 25 January 1931. The market on the Uilenburgerstraat specialized in second-hand goods fish, and other food products, including the ever-popular ‘Jewish pickles’. The Depression in the 1930s led to unemployment in many trades, including the diamond industry, where many Jews had worked. As a consequence, the number of market vendors and peddlers increased in the 1930s. In September 1941 the Nazis prohibited Jews from trading at public markets. Special markets where only Jews were allowed to trade opened nearby. Very few Jewish market and street vendors survived the war. The Uilenburgerstraat market never reopened (info source https://www.joodsmonument.nl/en/page/671/jewish-market-and-street-vendors-in-amsterdam ). Footage thanks to Netherlands Institute for Sound and Vision (Open Images).

* Note – Yesterday’s film (Mokum Market version 20190814) seems sped up – probably because of a wrong play speed when scanned for digitalisation). Thus , I post this new version today, sloweddown to 75% speed at play back – based subjectively on how motion of people looks , and based on other writings that silent films are often distributed with instructions for the projectionist to be run at 18fps , rather then the modern 24 frames per second – thus requiring a 18/24 = 75% fps.

Mokum Market ~ Amsterdam Jewish Quarter 1931


Sunday outdoor market in the ‘Nieuwe Uylenburgerstraat’ street in the Jewish quarter of Amsterdam (Mokum). Dutch Polygoon cinema newsreel 25 January 1931. The market on the Uilenburgerstraat specialized in second-hand goods fish, and other food products, including the ever-popular ‘Jewish pickles’. The Depression in the 1930s led to unemployment in many trades, including the diamond industry, where many Jews had worked. As a consequence, the number of market vendors and peddlers increased in the 1930s. In September 1941 the Nazis prohibited Jews from trading at public markets. Special markets where only Jews were allowed to trade opened nearby. Very few Jewish market and street vendors survived the war. The Uilenburgerstraat market never reopened (info source https://www.joodsmonument.nl/en/page/671/jewish-market-and-street-vendors-in-amsterdam ). Footage thanks to Netherlands Institute for Sound and Vision (Open Images).
① memo 20190814 ~ Mokum Market .

Update 20190815

Film playback seems sped up. Thus , I posted a new version the next day, slowed-down to 75% speed at play back – see post 20190815.