Pittsburgh 1992 Cell Transplant Society • 20240812

Poster Cell Transplant Society, Pittsburgh (USA) June 3, 1992 • 20240812_1 • michelvanderburg•com • TakeNode ca498136-3e99-4486-b641-f9f61894f19c

Updated 20250115

Congress

Pittsburgh (USA) May 31–June 3, 1992. Founding meeting, and 1st Int. Congress of the Cell Transplant Society.

Michel van der Burg, Co-chair ‘Methods’ Poster Discussion CTS , Pittsburgh June 3, 1992 • 20240812_2 • michelvanderburg•com • TakeNode 509ce973-d218-4f9c-84ef-ffa7c4fdb0d1

Poster creation

The poster was designed and produced May 1992 on a Macintosh computer using MacDraw II (with bar graphs from Cricket Graph) and printed landscape across a chain of several sheets of paper using the Imagewriter dotmatrix printer.

For this 2024 remastered poster below, the 1992 MacDraw II file was converted and edited using LibreOffice Vanilla, and next Pixelmator Pro was used for additional ‘repair’ (conversion issues with the many layers used for ‘tubes’ creation) and the insertion of the photo scans.

Poster Pittsburgh 1992 Cell Transplant Society, remastered • 20240812_3 • michelvanderburg•com • TakeNode 26159e06-9f29-4fab-a5f3-a595469b352e

Notes

Van der Burg MPM, Guicherit OR, Scherft JP, Bruijn JA, Frölich M, Gooszen HG. Islet preservation during isolation: a new concept in cell transplantation. First International Congress of the Cell Transplant Society, Pittsburgh (USA) May 31 – June 3, 1992.

Van der Burg MPM, Guicherit OR, Frölich M, Bruijn JA, Gooszen HG. Islet preservation during isolation: a new concept in cell transplantation. Transplant Proc. 1992 Dec;24(6):2840-1. PMID: 1465965. PDF available below
PMID_1465965 🔗

Update dd 20250115 – proceedings paper PMID: 1465965 added

Citation info : Pittsburgh 1992 Cell Transplant Society • 20240812 • Michel van der Burg • michelvanderburg•com

Lucky #1 Islet • 20240811

Shortly after starting our Islet Lab end 1986, I hand-picked and photographed this special big heart-shaped isolated islet of Langerhans with Uncle Scrooge McDuck’s ‘lucky #1 dime’ in mind.
(dutch : Dagobert Duck’s geluksdubbeltje). This ‘First Islet’ poster was pinned to the wall in my study in the (small) Islet Lab ‘wing’ in the Cell Biology building of the Leiden University Hospital.

It’s an Islet of Langerhans isolated from a rat pancreas. For pilot work, the first months while developing our islet project plan, islets were isolated from rat pancreases.
I had started developing our basic lab methods… like eg. measuring the insulin secretion capacity and insulin content of isolated islets. A custom-made glass pipet was used to hand-pick and transfer the islets to little polypropyleen ‘Eppendorf’ tubes for insulin secretion tests with glucose stimulation.

Citation info : Lucky #1 Islet • 20240811 • Michel van der Burg • michelvanderburg•com | TakeNode 5234a6e0-4565-4167-bb46-0f922c0b1d2a

Minneapolis 1989 Poster | 20240804

September 1989 at a symposium of two international societies in Minneapolis, USA (1) , I presented this first poster on the ‘ invention ‘ of using the UW solution ( the University of Wisconsin organ preservation solution) during pancreatic islet isolation, with the exciting discovery of near-complete purification of islets of Langerhans in the laboratory for transplantation in diabetic patients.

Here the remastered 20240804 edition of that Minneapolis 1989 poster presentation.

The UWS data had been added ad hoc in the poster – that is , it wasn’t part of the accepted abstract. The first proceedings paper on our UWS work was also submitted at this meeting , and was published April ’90 (3).

A previous edition of the remastered poster was published here two years ago (2) but that edition had a different photo print (higher magnification, and without the bar indicator) of the purified islet preparation inserted, not the original image. This has been corrected now. In addition the original line spacing is now restored.

Notes

1) Van der Burg MPM, Gooszen HG, Ploeg RJ, Scherft JP, Field MJ, Guicherit OR, Terpstra JL, Van de Woude FT, Frölich M, Bruijn JA. Comparison of islet isolation techniques in dogs: Over 90% purified islets using UW solution. 4th International Symposium on Organ Procurement and Preservation and 2nd International Congress on Pancreatic and Islet Transplantation, Minneapolis (USA) September 17–22, 1989.

2) Minneapolis 1989 Poster UW Solution Islet Isolation | 20220822 | Michel van der Burg | michelvanderburg•com | URL https://michelvanderburg.com/2022/08/22

3). Van der Burg MPM, Gooszen HG, Ploeg RJ, Scherft JP, Field MJ, Guicherit OR, Terpstra JL, Van de Woude FJ, Frölich M, Bruijn JA. Comparison of islet isolation techniques in dogs: Over 90% purified islets using UW solution. Transplant Proc. 1990 Apr;22(2):795-6. PMID: 2158174.
This paper appears to be not readily available online – a reprint copy is available here PMID_2158174 🔗

PMID_2158174 Download

Updates

20241211 : Minor text updates

20260128 : Added Reference 3 and pdf file of the proceedings paper

Citation info : Minneapolis 1989 Poster | 20240804 | Michel van der Burg | michelvanderburg•com | TakeNode 91d70715-3fb3-4380-906a-0daf1b5ddd6a

Leiden Islet Laboratory History • 20240803

Summer 1985… start of our Leiden Islet Transplant Laboratory by Paul van Suylichem (right) and Michel van der Burg (middle), both from the Surgery department — wondering how to start here our islet lab in this space – a former weighing chamber (left : stable weighing table) made available by the Cell Biology department of the Leiden University, headed by Prof J.P. Scherft. Where to put our equipment… the laminar flow cabinet, large centrifuge, fridge, freezer, shaking waterbath, microscopes, and a lot of disposables coming ?

I had started working in 1981 for the Pancreas project. Pancreas transplantation research with the surgeon Hein Gooszen , working on his PhD (1), and surgeon Reinout van Schilfgaarde – who headed the project – and in 1985 also started this islet project.

Summer 1986, when Reinout van Schilfgaarde together with Paul van Suylichem moved to the Groningen University Hospital (2), Hein Gooszen and I decided to make a fresh start with the now operational Leiden Islet Lab…

Fifteen years of research later we were ready to roll with the isolation of human islets of Langerhans, in our new GMP facility in the Leiden Univerity Medical Center (LUMC). September 2001, the National Health Care Institute positively assessed our permit application for Transplantation of Islets of Langerhans in the LUMC (3,6), followed by approval May 2003 of the islet bank by the Health and Youth Care Inspectorate of the Ministry of Health, Welfare and Sport (VWS).

Notes

Post last update : 20241010-1611

Gooszen HG. Canine segmental pancreatic autotransplantation. Analysis of the effects of ductobliteration. Thesis, Leiden, 1984
Benoemd – Te Groningen dr.R.van Schilfgaarde tot hoogleraar in de heelkunde. Ned Tijdschr Geneeskd. 1986;130:2240 | URL https://www.ntvg.nl/artikelen/personalia-7848
Advies vergunningsaanvraag transplantatie Eilandjes van Langerhans | Op 27 september 2001 uitgebracht aan de minister van Volksgezondheid, Welzijn en Sport. | Rapport 01/71 | C.R. Smand, J.P. Verduijn / College voor Zorgverzekeringen. URL https://data.bibliotheken.nl/id/nbt/p229940978
Update 20240807. Added some history, and made minor changes.
Update 20240828 minor correction date (Fresh start lab ‘At the end of 1986’ changed to Summer 1986.)
Update 20241010, added : Press release Sep 27, 2001 by National Health Care Institute (CVZ). Transplantatie Eilandjes van Langerhans naar LUMC 27 september 2001. CVZ adviseert over vergunning. John van der Pas, persvoorlichter CVZ. Source : Razende Robot Reporter | Nieuwsbank Interactief Nederlands persbureau .
Retrieved 20090313 from Nieuwsbank.nl (link expired, domain has new owner).
20241010 PDF (Ads , and author phone number redacted by M.P.M. van der Burg | Miracles•Media) file 20241010_CVZ • URL michelvanderburg.com/2024/10/10

20241010_CVZ

Citation info : Leiden Islet Laboratory History • 20240803 | Michel van der Burg | michelvanderburg•com | TakeNode fad1be86-34f2-453f-b477-2abc62e467be

Stellingen | Addendum e-Book ISBN_9789080216402 | 20221026

Stellingen | Addendum e-Book ISBN_9789080216402 | 20221026 | Michel van der Burg | Miracles•Media

Free download available now of the Addendum e-book (pdf) ‘Propositions | Stellingen (dutch)’ belonging to the dissertation ‘Pancreatic islet transplantation’ by Michel P.M. van der Burg (addendum eBook ISBN 9789080216402) .

Download available at Miracles.Media page https://miracles.media/pancreatic-islet-transplantation-ebook-isbn-9789080216402/

Note : The Dutch dissertation system has a tradition of accompanying the generally very specialised PhD thesis with ten or more propositions (other ‘theses’), that should be ‘defensible’, and while at least some should be related to the dissertation, others generally reflect the PhD candidate’s broader interests, and the last one is often playful.

TAGS #addendum #stellingen #propositions #ebook #transplantation #islets #technology #thesis #medicine #ISBN9789080216402 #book #release #distibution #cover #FrenchFlap #flap #publish #blurb #science #donor #pancreas #insulin #therapy #clinical #isletsofLangerhans #isolation #University #Wisconsin #solution #UWS #density #gradient #separation #biology #diabetes #IDDM #laboratory #research #cure #Leiden #University #LUMC #dissertation #PhD #DoctorofPhilosophy #publisher #scan #ISBN9789080216419 #Holland #Netherlands #TakeNode #MiraclesMedia #1Memo #michelvanderburg

Pancreatic islet transplantation | eBook ISBN 9789080216402

Pancreatic islet transplantation | eBook ISBN 9789080216402 | 20221025 | Michel van der Burg | Miracles•Media

Pancreatic islet transplantation : studies on the technique and efficacy of islet isolation and transplantation. PhD Thesis (English) by Michel P.M. van der Burg.

The doctoral thesis ‘Pancreatic islet transplantation’ was published first as a paperback in 1994 — and obviously that is considered virtually inaccessible in this digital age. Now this e-Book edition has been produced and released by the author / publisher Michel van der Burg | Miracles•Media as a free download , available from October 25th, 2022.

Preview & Download

Preview & download eBook ‘Pancreatic islet transplantation’ by Michel van der Burg | ISBN eBook (pdf) 978-90-802164-0-2 for free at the author’s / publishers’ site Miracles•Media here :
https://miracles.media/pancreatic-islet-transplantation-ebook-isbn-9789080216402/

Support – For people who would like to also support my work – you can … ‘Buy me a coffee’ there too 😉

eBook details

Title : Pancreatic islet transplantation : Studies on the technique and efficacy of islet isolation and transplantation

Author : Michel P.M. van der Burg

Publisher : M.P.M. van der Burg | Miracles.Media

Genre : Medicine Technology & Science & Nature

Released : October 25, 2022

Language : EN English & Dutch summary

Length : 192 pages / 68 MB

Format : PDF (full access, no DRM, searchable PDF – designed for long term accessibility and archive PDF/A-1b – PDF/UA)

Version : Reprinted 1st edition (2nd impression) as eBook (pdf ISBN 9789080216402) by author / publisher M.P.M. van der Burg from scanned paperback published in 1994 by M.P.M. van der Burg (ISBN paperback 9789080216419).

Requirements : You can view this book on any device, best with a tablet or larger screen.

Addendum : Propositions | Stellingen (dutch) – published – release here will follow later.

Review / Award : Glaxo Wellcome Gastrointestinal Research Award – 2nd Prize – awarded October 5, 1995 to Michel P.M. van der Burg for the dissertation “Pancreatic islet transplantation” (received at the Fall meeting of the Dutch Gastroenterology Society, Veldhoven, The Netherlands)

File name : 9789080216402_ISBN.pdf

TakeNode ID : b9a348fd-9f3e-4f02-af51-e1ab25d61522

Publisher’s description

Pancreatic islet transplantation by a new method is introduced here : the isolation of islets in an organ preservation solution, the University of Wisconsin solution. A new concept allowing for the first time large-scale isolation and transplantation of consistently near 100% pure islets of Langerhans in a preclinical dog model with fasting normoglycemia up to 3 years posttransplant. Detailed metabolic studies demonstrated normal insulin levels after meals with preservation of gut hormone action stimulating insulin secretion at the mild hyperglycemia after meals. The introduction of the University of Wisconsin solution organ preservation solution for islet isolation at the start of these studies in 1989 is a new concept … and has been shown by now in 2022 , world-wide , to make the future of islet isolation and transplantation methods for insulin-dependent diabetes mellitus (IDDM).

TAGS #ebook #transplantation #islets #technology #thesis #medicine #ISBN9789080216402 #book #release #distibution #cover #FrenchFlap #flap #publish #blurb #science #donor #pancreas #insulin #therapy #clinical #isletsofLangerhans #isolation #University #Wisconsin #solution #UWS #density #gradient #separation #biology #diabetes #IDDM #laboratory #research #cure #Leiden #University #LUMC #dissertation #PhD #DoctorofPhilosophy #publisher #scan #ISBN9789080216419 #Holland #Netherlands #TakeNode #MiraclesMedia #1Memo #michelvanderburg

Cover | Pancreatic islet transplantation | ISBN 9789080216402

Cover | Pancreatic islet transplantation | ISBN 9789080216402 | 20221024 | Michel van der Burg | Miracles•Media | PUBLISHED ! Here the full cover with a French flap back-cover of the e-Book (pdf) edition of my doctoral thesis ‘Pancreatic islet transplantation’ – ISBN 9789080216402 – published and registered today, Oct 24th, 2022 . In short : Pancreatic islet isolation in the University of Wisconsin solution is a new concept introduced here … allowing transplantation of pure islets as an effective treatment in insulin-dependent diabetes. Distribution of the e-Book and full information follows this week.

TakeNode ID: c50c9112-5763-4117-b31a-e818723e18a2

TAGS #cover #FrenchFlap #flap #publish #blurb #science #donor #pancreas #insulin #therapy #clinical #isletsofLangerhans #isolation #UniversityofWisconsin #solution #UWS #density #gradient #separation #transplantation #medicine #biology #diabetes #IDDM #laboratory #research #cure #LeidenUniversity #LUMC #dissertation #PhD #DoctorofPhilosophy #publisher #scan #ebook #book #ISBN9789080216402 #ISBN9789080216419 #Holland #Netherlands #TakeNode #MiraclesMedia #1Memo #michelvanderburg